Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.9K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.9K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

496
Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
496
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

829
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
829

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of an RNA extraction method to detect SARS-CoV-2 RNAemia in postmortem whole blood.

Legal medicine (Tokyo, Japan)·2026
Same author

Investigation of a simple suspension method for orexin receptor antagonist tablets.

Journal of pharmaceutical health care and sciences·2026
Same author

Extensive Alanine Scanning of Loop Regions in Ketosynthase Domains Identifies Non-Active Site Mutations with Drastic Effects on Polyketide Biosynthesis.

ACS chemical biology·2026
Same author

Risk assessment of SARS-CoV-2 infection from external surfaces and biological samples of COVID-19 corpses.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025
Same author

Anion-exchange high-performance liquid chromatography: A new approach to monitoring the formation of mRNA-loaded lipid nanoparticles during manufacturing.

Journal of pharmaceutical sciences·2025
Same author

An Infant Autopsy Case of Acute Appendicitis with Lymphoid Hyperplasia.

Pediatric reports·2025

Related Experiment Video

Updated: Apr 25, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

18.4K

Practical approach to prepare solid dispersion drug product using spherical silicate.

Kentaro Nagane1, Susumu Kimura2, Koji Ukai2

  • 1Pharmaceutical Science and Technologies, Eisai Co., Ltd., 1 Kawashimatakehaya-machi, Kakamigahara, Gifu 501-6195, Japan; Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto, Chikusaku, Nagoya, Aichi 464-8650, Japan.

International Journal of Pharmaceutics
|August 19, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for creating amorphous solid dispersion drugs using spherical silicate and a fluidized bed granulator. This technique successfully improved drug dissolution rates, offering a promising approach for pharmaceutical development.

Keywords:
IbuprofenIndomethacinMicrobead silicatePhenytoinSolid dispersionWurster-type fluidized bed granulator

More Related Videos

A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays
10:44

A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays

Published on: August 26, 2013

15.7K
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
07:37

Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition

Published on: December 21, 2015

8.8K

Related Experiment Videos

Last Updated: Apr 25, 2026

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

18.4K
A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays
10:44

A Guided Materials Screening Approach for Developing Quantitative Sol-gel Derived Protein Microarrays

Published on: August 26, 2013

15.7K
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
07:37

Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition

Published on: December 21, 2015

8.8K

Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Chemical Engineering

Background:

  • Developing amorphous solid dispersions is crucial for enhancing the bioavailability of poorly soluble drugs.
  • Traditional methods for preparing amorphous solid dispersions can be complex and may not achieve complete amorphization.
  • Spherical silicate offers a unique porous structure suitable for drug loading.

Purpose of the Study:

  • To develop a novel, efficient method for preparing amorphous solid dispersions using spherical silicate.
  • To evaluate the effectiveness of a Wurster-type fluidized bed granulator for this process.
  • To investigate the impact of spherical silicate properties on amorphous drug yield.

Main Methods:

  • Utilized a Wurster-type fluidized bed granulator to load model drugs (ibuprofen, indomethacin, phenytoin) onto spherical silicate.
  • Prepared amorphous drug products by loading drugs onto porous spherical silicate.
  • Compared the fluidized bed granulation method with spray drying for amorphization efficacy.
  • Assessed the dissolution profiles of the prepared amorphous solid dispersions.

Main Results:

  • All tested drugs (ibuprofen, indomethacin, phenytoin) were successfully loaded onto spherical silicate in an amorphous state.
  • The Wurster-type fluidized bed granulator approach achieved complete amorphization, unlike the reference spray drying method.
  • Significant improvements in drug dissolution rates were observed for all amorphous solid dispersions compared to crystalline forms.
  • Specific surface area and particle size of spherical silicate were identified as critical factors for high amorphous product yield.

Conclusions:

  • The proposed method using spherical silicate and a Wurster-type fluidized bed granulator is an effective strategy for preparing amorphous solid dispersions.
  • This approach significantly enhances the dissolution of poorly soluble drugs.
  • Optimizing the properties of spherical silicate, such as its specific surface area and particle size, is key to maximizing amorphous drug yield.