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Updated: Apr 25, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy
Yanhui Deng1, Tian Lan2, Juan Huang3
1Department of Pharmacy, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China.
Objective:
Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide and its prevalence continues to increase. Currently, therapies for DN provide only partial renoprotection; hence new targets for therapeutic intervention need to be identified. In this review, we summarized the new target, sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway, explored its potential therapeutic role in the prevention and treatment of DN.
Data Sources:
Most relevant articles were mainly identified by searching PubMed in English.
Study Selection:
Mainly original articles and critical review articles by major pioneer investigators in this field were selected to be reviewed.
Results:
SphK1/S1P pathway can be activated by hyperglycemia, advanced glycation end products, and many pro-inflammatory cytokines, which leads to fibronectin, transforming growth factor-β1 up-regulation and AP-1 activation. And then it could promote glomerular mesangial cells proliferation and extracellular matrix accumulation, mediating the initiation and progression of diabetic renal fibrosis.
Conclusions:
SphK1/S1P pathway is closely correlated with the pathogenesis of DN. The results suggest that SphK1/S1P pathway as a new target for clinically improving DN in future is of great prospect.
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