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Hedgehog Signaling Pathway02:33

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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[Progress on Hedgehog signaling transduction].

Ying Tang1, Steven Cheng

  • 1Central Laboratory, the First People's Hospital of Wujiang District, Suzhou 215200, China; Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, China. sycheng@njmu.edu.cn.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|August 19, 2014
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Summary
This summary is machine-generated.

The Hedgehog (Hh) signaling pathway is crucial for embryonic development and cancer. This review details its canonical and non-canonical pathways, focusing on Gli transcription factors and primary cilia roles.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cell Signaling

Background:

  • The Hedgehog (Hh) signaling pathway is vital for embryonic development and pattern formation.
  • Disruptions in Hh signaling are linked to developmental disorders and cancer.
  • Primary cilia act as critical signaling centers in vertebrate Hh signal transduction.

Purpose of the Study:

  • To provide a comprehensive review of the Hedgehog signaling pathway.
  • To elucidate the mechanisms of canonical Hh signaling involving Gli transcription factors.
  • To explore the emerging Gli-independent non-canonical Hh signaling pathways.

Main Methods:

  • Literature review of canonical and non-canonical Hh signaling.
  • Analysis of Hh pathway members and their regulation of Gli transcription factors.
  • Examination of the role of primary cilia in Hh signal transduction.

Main Results:

  • Mammalian Hh signaling regulates Gli transcription factors via a canonical pathway.
  • Hh signaling is highly conserved across species.
  • Non-canonical pathways, independent of Gli or Smo, represent a significant area of recent research.

Conclusions:

  • The Hedgehog pathway, encompassing both canonical and non-canonical routes, is fundamental to development and disease.
  • Understanding these pathways is crucial for addressing developmental abnormalities and cancer.
  • Further research into non-canonical Hh signaling promises new therapeutic insights.