Sequencing approaches in cancer treatment

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D Sekar1, K Thirugnanasambantham, V I Hairul Islam

  • 1Pondicherry Centre for Biological Sciences, Pondicherry, 605 005, India.

Cell Proliferation
|August 19, 2014
PubMed

Insights

Next-generation sequencing (NGS) advances cancer genomics by enabling rapid analysis of oncogenes and tumor suppressors. This review explores sequencing techniques crucial for understanding cancer alterations and guiding therapy.

Area of Science:

  • Genomics
  • Oncology
  • Molecular Biology

Background:

  • Cancer genomics relies heavily on sequencing approaches to identify genetic alterations.
  • Next-generation sequencing (NGS) technologies have revolutionized the rapid analysis of oncogenes and tumor-suppressor genes.
  • Various genomic alterations, including point mutations, copy number variations, and epigenetic changes, are critical in cancer development.

Purpose of the Study:

  • To review current sequencing techniques in cancer genomics.
  • To highlight the importance of these techniques in cancer therapy and treatment strategies.
  • To discuss the impact of technological advancements on genomic analysis in oncology.

Main Methods:

  • Exploration of various next-generation sequencing (NGS) technologies.
  • Review of deep sequencing techniques for comprehensive genomic analysis.
  • Analysis of advancements like the $1000 Genome Project.

Main Results:

  • NGS enables efficient sequencing of key cancer-related genes.
  • Technological progress has led to increased accuracy and depth in genomic analysis.
  • Sequencing data provides insights into diverse cancer-related genomic modifications.

Conclusions:

  • Sequencing techniques are fundamental tools in cancer genomics research.
  • Advancements in sequencing are critical for personalized cancer therapy and treatment.
  • Understanding genomic alterations through sequencing drives progress in oncology.

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