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Updated: Apr 25, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Development of novel membrane active lipidated peptidomimetics active against drug resistant clinical isolates
Sandeep Lohan1, Arneesh Kalanta1, Praveen Sonkusre2
1Department of Pharmacy, Jaypee University of Information Technology, Solan 173234, India.
Abstract:
A new series of small cationic lipidated peptidomimetics have been synthesized and found to be highly active against several susceptible as well as drug resistant clinical isolates of bacteria and fungi. All lipidated peptidomimetics do not cause significant lysis of human erythrocytes (HC50>200μg/mL). Calcein dye leakage experiment revealed membranolytic effect of LPEP08 which was further confirmed by scanning electron microscopy (SEM). The involvement of intracellular targets as an alternate mode of action was precluded by DNA retardation assay. Additionally, LPEP08 exhibit high proteolytic stability and dose not elicit resistance against drug resistant clinical isolate of Staphylococcusaureus, even after 16 rounds of passaging. These results demonstrate the potential of lipidated peptidomimetics as biocompatible anti-infective therapeutics.
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