Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

839
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
839
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

701
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
701
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

1.9K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.9K
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

2.4K
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.4K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.9K
Structure of Lipids03:38

Structure of Lipids

87.5K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
87.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipid-related cardiovascular risk beyond low-density lipoprotein cholesterol.

Heart (British Cardiac Society)·2026
Same author

Feasibility of remnant cholesterol as a therapeutic target for atherosclerotic cardio-vascular disease.

Expert opinion on therapeutic targets·2026
Same author

VLDL cholesterol and ASCVD risk: A population-based study.

Journal of clinical lipidology·2026
Same author

Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study.

Atherosclerosis·2025
Same author

The association between small dense low-density lipoprotein cholesterol and peripheral artery disease: a large-scale cohort study and meta-analysis.

European journal of preventive cardiology·2025
Same author

Remnant Cholesterol: Quantification, Concentrations by Sex and Age, and Risk of Ischemic Heart Disease.

Clinical chemistry·2024

Related Experiment Video

Updated: Apr 25, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

3.7K

Triglycerides and cardiovascular disease.

Børge G Nordestgaard1, Anette Varbo1

  • 1Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Lancet (London, England)
|August 19, 2014
PubMed
Summary

Raised triglyceride levels are increasingly recognized as a significant risk factor for cardiovascular disease and mortality. New triglyceride-lowering drugs and ongoing trials aim to confirm their cardiovascular benefits.

Related Experiment Videos

Last Updated: Apr 25, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

3.7K

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Pharmacology

Background:

  • Clinical focus has shifted from LDL cholesterol and HDL cholesterol to triglycerides.
  • Genetic and epidemiological evidence highlights triglycerides, remnant cholesterol, and triglyceride-rich lipoproteins as cardiovascular disease (CVD) risk factors.
  • Low HDL cholesterol may not be as causative of CVD as previously thought.

Purpose of the Study:

  • To review the current understanding of the role of triglycerides in cardiovascular disease.
  • To discuss the implications of new evidence and drug development in triglyceride management.

Main Methods:

  • Review of genetic studies and randomized controlled trials.
  • Analysis of epidemiological data on triglyceride levels and cardiovascular risk.
  • Discussion of current and emerging triglyceride-lowering therapies.

Main Results:

  • Triglyceride concentrations between 2-10 mmol/L are associated with increased CVD risk.
  • Triglyceride levels >10 mmol/L increase the risk of acute pancreatitis and potentially CVD.
  • Evidence supporting cardiovascular benefit from triglyceride reduction in randomized trials is limited but emerging.

Conclusions:

  • There is renewed interest in triglycerides as a key factor in cardiovascular disease.
  • New triglyceride-lowering drugs are under development, with large trials underway.
  • Conclusive evidence on the cardiovascular benefits of triglyceride reduction is anticipated from ongoing research.