Related Experiment Video
Updated: Apr 25, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant
1Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary.
Abstract:
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action on sodium and calcium channels are summarized as recently significantly new data were reported.
Related Concept Videos
Desensitization and Tachyphylaxis
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Pharmacodynamic Responses: Different Types
Drug Distribution: Tissue Binding
For...
Factors Affecting Drug Response: Overview

