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A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents
Published on: September 21, 2021
Pediatric heart transplantation-indications and outcomes in the current era
Philip T Thrush1, Timothy M Hoffman1
11 The Heart Center, Nationwide Children's Hospital, 2 Department of Pediatrics, The Ohio State University, Columbus, OH, USA.
Insights
Pediatric heart transplantation (HTx) is crucial for end-stage heart disease in children. Research collaboratives significantly improve evidence for evolving HTx indications and outcomes.
Area of Science:
- Pediatric Cardiology
- Cardiovascular Surgery
- Transplantation Medicine
Background:
- Pediatric heart transplantation (HTx) is a vital treatment for end-stage heart disease in children, including those with cardiomyopathy and congenital heart disease (CHD).
- Improved surgical outcomes for CHD necessitate dynamic adjustments in HTx indications for both pediatric and adult CHD populations.
- The evolution of pediatric HTx is marked by enhanced outcomes, driven by dedicated research.
Purpose of the Study:
- To review current indications for pediatric heart transplantation.
- To analyze outcomes of pediatric heart transplantation.
- To emphasize the role of research collaboratives in advancing pediatric HTx.
Main Methods:
- Focus on studies generated by research collaboratives like the International Society for Heart and Lung Transplantation (ISHLT) and the Pediatric Heart Transplant Study (PHTS) group.
- Analysis of pooled data from collaborative research to address limitations of single-center studies.
- Review of literature focusing on indications and outcomes in pediatric HTx.
Main Results:
- Research collaboratives provide essential evidence for practice evolution in pediatric HTx.
- Pooled experience from collaboratives is crucial for understanding rare complications affecting long-term graft survival.
- Improved outcomes in pediatric HTx are linked to collaborative research efforts.
Conclusions:
- Pediatric HTx indications must adapt to evolving surgical success in CHD.
- Collaborative research is indispensable for generating robust evidence in pediatric HTx.
- Continued research through collaboratives is key to improving long-term graft survival and overall outcomes in pediatric heart transplantation.
Abstract:
Pediatric heart transplantation (HTx) remains an important treatment option in the care of children with end-stage heart disease, whether it is secondary to cardiomyopathy or congenital heart disease (CHD). As surgical outcomes for CHD have improved, the indications for pediatric HTx have had to be dynamic, not only for children with CHD but also for the growing population of adults with CHD. As the field of pediatric HTx has evolved, the outcomes for children undergoing HTx have improved. This is undoubtedly due to the continued research efforts of both single-center studies, as well as research collaboratives such as the International Society for Heart and Lung Transplantation (ISHLT) and the Pediatric Heart Transplant Study (PHTS) group. Research collaboratives are increasingly important in pediatric HTx as single center studies for a limited patient population may not elicit strong enough evidence for practice evolution. Similarly, complications that limit the long term graft survival may occur in a minority of patients thus pooled experience is essential. This review focuses on the indications and outcomes for pediatric HTx, with a special emphasis on studies generated by these research collaboratives.
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