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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

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Primary renal angiosarcoma with extensive necrosis: a difficult diagnosis.

Sohail Qayyum¹, Jignesh G Parikh¹, Nadeem Zafar¹

¹Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Case Reports in Pathology

|August 19, 2014

Summary

Primary renal angiosarcoma, a rare and aggressive kidney cancer, can present as a necrotic renal mass. Early inclusion in differential diagnoses is crucial for prompt identification and treatment.

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Published on: July 3, 2013

Area of Science:

Oncology
Pathology
Radiology

Background:

Angiosarcoma of the kidney is an exceptionally rare and aggressive neoplasm.
Few cases of primary renal angiosarcoma have been documented in medical literature.
Renal masses with extensive necrosis pose diagnostic challenges.

Purpose of the Study:

To report a rare case of primary renal angiosarcoma with extensive necrosis.
To discuss the diagnostic difficulties associated with this rare entity.
To emphasize the importance of considering renal angiosarcoma in the differential diagnosis of necrotic renal lesions.

Main Methods:

Case presentation of an 86-year-old male with a large necrotic renal mass and metastatic nodules.
Utilized CT-guided renal biopsy for tissue sampling.
Employed morphologic assessment and immunohistochemical studies for definitive diagnosis.

Main Results:

The patient presented with a 12 cm necrotic renal mass and widespread pulmonary and hepatic nodules.
Biopsy findings included extensive necrosis and vascular channels with malignant endothelial cells.
Diagnosis was confirmed through morphological and immunohistochemical analysis.

Conclusions:

Primary renal angiosarcoma is a rare diagnosis that must be considered in cases of necrotic renal masses.
The aggressive nature of this tumor necessitates early recognition.
Differential diagnosis for necrotic renal lesions should include this rare entity.