Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Analysis of Manually and Automatically Classified Circulating Tumor Biomarkers and their Prediction of Survival in Metastatic Colorectal Cancer.

Clinical pharmacology and therapeutics·2025
Same author

PSA Secretion from Single Circulating Tumor Cells of Metastatic Castration-Naïve Prostate Cancer Patients.

Cancer research communications·2025
Same author

Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages.

Acta pharmaceutica Sinica. B·2025
Same author

Performance comparison of streptavidin magnetic beads for epcam expressing cancer cell lines for circulating tumor cell (CTC) enrichment in a flow-through immunomagnetic system.

PloS one·2025
Same author

Clinical Validity of Repeated Circulating Tumor Cell Enumeration as an Early Treatment Monitoring Tool for Metastatic Breast Cancer in the PREDICT Global Pooled Analysis.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Secretome Analysis of Prostate Cancer Cell Lines Reveals Cell Cycle-Dependent PSA Secretion and Potential Biomarkers.

Cancers·2025

Related Experiment Video

Updated: Apr 25, 2026

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

15.1K

Detection of circulating tumor cells.

Sanne de Wit1, Guus van Dalum1, Leon W M M Terstappen1

  • 1Department of Medical Cell BioPhysics, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Carre, Room C4437, Hallenweg 23, 7522 NH Enschede, The Netherlands.

Scientifica
|August 19, 2014
PubMed
Summary
This summary is machine-generated.

Detecting circulating tumor cells (CTCs) in blood offers a noninvasive method to assess cancer treatment effectiveness. This review explores CellSearch technology for tracking CTCs in metastatic carcinomas.

More Related Videos

Capture and Release of Viable Circulating Tumor Cells from Blood
08:10

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

8.2K
Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
10:29

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

10.1K

Related Experiment Videos

Last Updated: Apr 25, 2026

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

15.1K
Capture and Release of Viable Circulating Tumor Cells from Blood
08:10

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

8.2K
Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
10:29

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

10.1K

Area of Science:

  • Oncology
  • Biotechnology
  • Medical Diagnostics

Background:

  • Metastatic carcinomas necessitate effective monitoring of treatment response.
  • Current monitoring methods may be invasive or lack real-time quantitative analysis.
  • Circulating tumor cells (CTCs) in blood present a potential noninvasive biomarker.

Purpose of the Study:

  • To review the CellSearch technology for detecting circulating tumor cells (CTCs).
  • To discuss the utility of CTCs in monitoring cancer therapy effectiveness.
  • To explore future improvements in CTC detection methods.

Main Methods:

  • Review of existing literature on CellSearch technology.
  • Analysis of the application of CTC detection in various carcinomas.
  • Discussion of technological advancements and limitations.

Main Results:

  • CellSearch technology enables the detection and enumeration of CTCs.
  • CTCs are shed during metastasis and can be found in peripheral blood.
  • Quantitative analysis of CTCs can provide insights into tumor burden and treatment response.

Conclusions:

  • Circulating tumor cell detection, particularly using CellSearch, is a promising noninvasive approach for monitoring cancer therapy.
  • Further technological advancements are needed to enhance sensitivity and expand applications.
  • CTC analysis holds potential for personalized medicine in oncology.