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Updated: Apr 25, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
TGF-β mediated DNA methylation in prostate cancer
Chung Lee1, Qiang Zhang2, Xaolin Zi3
1The Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Department of Urology, the University of California at Irvine, CA 92868, USA ; The Department of Pathology and Laboratory Medicine, the University of California at Irvine, CA 92697, USA.
Abstract:
Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.
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