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Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K
Allergic Reactions02:06

Allergic Reactions

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Overview
26.2K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

349
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
349
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

275
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
275
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

201
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
201
Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis
07:12

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis

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Immediate hypersensitivity reaction with mango.

Ashok Shah1, Kamal Gera

  • 1Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India. ashokshah99@yahoo.com.

Pneumonologia I Alergologia Polska
|August 19, 2014
PubMed
Summary
This summary is machine-generated.

Mango allergy is rare, presenting as immediate or delayed reactions. This case highlights immediate type I hypersensitivity, emphasizing timely diagnosis to prevent severe outcomes.

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Area of Science:

  • Immunology
  • Allergology
  • Dermatology

Background:

  • Hypersensitivity reactions to mango fruit are exceptionally uncommon.
  • Documented cases since 1939 total only 22, with distinct immediate (Type I) and delayed reactions.
  • Atopic history and geographic origin may correlate with reaction type.

Observation:

  • Immediate reactions are more prevalent in individuals with a history of atopy.
  • Delayed hypersensitivity cases have been reported predominantly from Australia.
  • Immediate reactions have been more frequently observed in Europe.

Findings:

  • This report details a 50-year-old male experiencing immediate Type I hypersensitivity to mango.
  • Symptoms included cough, wheezing, dyspnea, generalized itching, and abdominal discomfort post-ingestion.
  • The case underscores the potential for severe, life-threatening allergic events.

Implications:

  • Prompt diagnosis of mango allergy is crucial for effective management.
  • Preventing significant morbidity and potential mortality necessitates timely identification and intervention.
  • Understanding the varied presentations of mango hypersensitivity aids clinical practice.