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[Conjunctival amyloidosis].

Katerina Hufendiek1, K Hufendiek, L Metzger

  • 1Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Deutschland, katerina.hufendiek@klinik.uni-regensburg.de.

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Summary
This summary is machine-generated.

This case report details a rare instance of conjunctival amyloidosis (AL amyloidosis) caused by lambda light chains. Complete surgical excision was successful in treating this localized ocular condition.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Primary localized conjunctival lambda light-chain (AL) amyloidosis is an exceptionally rare condition.
  • This report details a unique case presentation and management of this rare ocular disease.

Observation:

  • A 73-year-old woman presented with a year-long history of a painless conjunctival mass.
  • Histopathological and immunohistochemical analyses confirmed interstitial and vascular amyloid deposits of lambda light chains.

Findings:

  • The patient underwent chemotherapy with melphalan and prednisolone for persistent conjunctival AL amyloidosis.
  • Complete surgical excision of the conjunctival mass resulted in no recurrence at 44 months follow-up.
  • Systemic evaluation excluded systemic amyloidosis, and MRI confirmed no cranial or orbital infiltration.

Implications:

  • Conjunctival AL amyloidosis is a rare entity requiring accurate diagnosis through identification of amyloid deposits.
  • Systemic involvement must be excluded due to the heterogeneous presentation and potential progression of amyloidosis.
  • Complete excision may be a viable treatment option for localized conjunctival AL amyloidosis.