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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Calcium supplementation in chronic kidney disease
Sushant Ramdas Taksande1, Elaine M Worcester
1University of Chicago, Nephrology , 5841 S Maryland Avenue, Chicago, IL, 60637 , USA eworcest@uchicago.edu.
Expert Opinion on Drug Safety
|August 20, 2014
Summary
Calcium supplementation and binders may increase vascular calcification risk in chronic kidney disease (CKD) patients. Current intake guidelines may need revision, potentially lowering the calcium limit to 1 gram daily.
Area of Science:
- Nephrology
- Cardiovascular Health
- Mineral Metabolism
Background:
- High prevalence of calcium supplementation in the general population.
- Calcium-based binders are standard for hyperphosphatemia in chronic kidney disease (CKD).
- These binders contribute significantly to calcium intake.
Purpose of the Study:
- Assess implications of calcium loading in CKD patients.
- Evaluate the role of calcium supplementation and binders in CKD.
- Review existing data on calcium intake and vascular health in CKD.
Main Methods:
- Review of observational studies and clinical trials.
- Analysis of balance studies on calcium loading in CKD.
- Evaluation of endpoints including vascular calcification, mortality, and bone morphology.
Main Results:
- Existing data raise concerns regarding calcium supplementation and binder use in renal compromise.
- Calcium loading implications in CKD require further investigation.
- Vascular calcification is a significant endpoint linked to calcium intake.
Conclusions:
- Current guidelines for calcium intake in renal failure may need reconsideration.
- An upper limit of 1 gram of calcium daily (including supplements/binders) may be safer for CKD patients.
- The previous Kidney Disease Outcomes Quality Initiative suggestion of 2 g may be too high.
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