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Total calcium-sensing receptor expression in circulating monocytes is increased in rheumatoid arthritis patients with

Julien Paccou, Cédric Boudot, Cédric Renard

    Arthritis Research & Therapy
    |August 20, 2014
    PubMed

    Insights

    Rheumatoid arthritis patients with severe coronary artery calcification show increased calcium-sensing receptor (CaSR) expression in monocytes. This finding highlights a potential link between CaSR and vascular calcification severity in RA.

    Area of Science:

    • Immunology
    • Cardiovascular Medicine
    • Rheumatology

    Background:

    • Human circulating monocytes express the calcium-sensing receptor (CaSR).
    • Monocytes play a role in atherosclerosis.
    • Rheumatoid arthritis (RA) is associated with increased cardiovascular risk, including vascular calcification.

    Purpose of the Study:

    • To investigate the association between vascular calcification in RA patients and CaSR expression in circulating monocytes.
    • To compare CaSR expression in monocytes of RA patients with and without significant vascular calcification.

    Main Methods:

    • Cross-sectional study comparing 50 RA patients and 25 controls.
    • Isolation of peripheral blood mononuclear cells and flow cytometry for CaSR expression analysis.
    • Computed tomography for coronary artery calcium (CAC) and abdominal aortic calcification (AAC) scoring.

    Main Results:

    • No significant difference in CAC or AAC burden between RA patients and controls.
    • RA patients with severe CAC (Agatston score ≥ 200) exhibited significantly higher total CaSR expression in monocytes compared to those with mild-to-moderate CAC (P = 0.01).
    • No significant difference in surface CaSR expression was observed between groups.

    Conclusions:

    • Total CaSR expression in circulating monocytes is elevated in RA patients with severe coronary artery calcification.
    • This suggests a potential role for CaSR in the pathogenesis of vascular calcification in RA.
    • Further research is warranted to explore CaSR as a therapeutic target in RA-associated cardiovascular disease.
    Abstract

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