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Related Experiment Videos

Chronic mountain sickness in Tibet.

S X Pei1, X J Chen, B Z Si Ren

  • 1Workers' Hospital of the Tibet Autonomous Region of the People's Republic of China, Lhasa, Tibet.

The Quarterly Journal of Medicine
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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Chronic mountain sickness affects Han immigrants in Lhasa, causing polycythaemia and later cardiopulmonary issues. The condition worsens with prolonged high-altitude exposure and is linked to smoking.

Area of Science:

  • Altitude Medicine
  • Cardiopulmonary Physiology
  • Hematology

Background:

  • Chronic mountain sickness (CMS) is prevalent in Lhasa, Tibet, affecting immigrant Han populations.
  • The syndrome mimics Andean CMS, developing after prolonged high-altitude residence (average 15 years).
  • CMS is rare in women and native Tibetans, with smoking as a potential contributing factor.

Purpose of the Study:

  • To describe the clinical features and pathophysiology of CMS in Lhasa.
  • To investigate the progression from early polycythemic symptoms to later cardiopulmonary involvement.
  • To identify risk factors and demographic patterns associated with CMS in this population.

Main Methods:

  • Clinical observation and symptom assessment.
  • Polycythaemia evaluation through blood parameters.

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  • Hemodynamic measurements including cardiac output and ventricular function.
  • Respiratory gas analysis to assess ventilation-perfusion relationships.

    • Main Results:

    • Early symptoms include headache, dizziness, memory loss, and fatigue, linked to polycythaemia.
    • Later stages manifest with dyspnoea and peripheral edema.
    • Hemodynamic studies reveal pulmonary hypertension, normal cardiac output, and right ventricular dilatation.
    • Respiratory analysis indicates alveolar hypoventilation and ventilation-perfusion inhomogeneity.

    Conclusions:

    • CMS in Lhasa is characterized by initial polycythaemia progressing to cardiopulmonary disease with prolonged high-altitude exposure.
    • Pathophysiology involves alveolar underventilation and ventilation-perfusion mismatch.
    • Understanding these mechanisms is crucial for managing CMS in high-altitude populations.