Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The critical role of the endogenous immune compartment after CAR T cell therapy in recurrent GBM.

Cell·2026
Same author

Modeling Gliomas with Organoids: Classification, Fidelity, and Guidelines for Translational Neuro-Oncology.

Neuro-oncology·2026
Same author

Author Correction: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.

Nature neuroscience·2026
Same author

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain.

bioRxiv : the preprint server for biology·2026
Same author

Transsynaptic tracing techniques to interrogate neuronal connectivity of glioblastomas.

Nature protocols·2026
Same author

The need for a global effort to attend to human neural organoid and assembloid research.

Science (New York, N.Y.)·2025

Related Experiment Video

Updated: Apr 25, 2026

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
08:03

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Published on: September 19, 2019

6.0K

DNA modifications in the mammalian brain.

Jaehoon Shin1, Guo-Li Ming2, Hongjun Song3

  • 1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|August 20, 2014
PubMed
Summary

DNA methylation is a key epigenetic regulator in development and neuronal function. This review covers DNA modification principles, brain genome profiles, and their roles in brain development and cognition.

Keywords:
5-hydroxymethylcytosine5-methylcytosineDNA methylationlearning and memory

More Related Videos

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

6.8K
Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.5K

Related Experiment Videos

Last Updated: Apr 25, 2026

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice
08:03

The Detection of 5-Hydroxymethylcytosine in Neural Stem Cells and Brains of Mice

Published on: September 19, 2019

6.0K
Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
10:09

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark

Published on: January 26, 2018

6.8K
Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

2.5K

Area of Science:

  • Epigenetics and Molecular Biology
  • Neuroscience

Background:

  • DNA methylation is a fundamental epigenetic mark essential for mammalian development, genomic stability, and gene regulation.
  • Emerging evidence highlights the significance of DNA methylation in neuronal functions, including learning and memory.

Purpose of the Study:

  • To review recent advances in DNA modifications within the broader epigenetics field.
  • To delineate the distinct profiles of DNA modifications in the mammalian brain genome.
  • To discuss the functional implications of DNA modifications in brain development and overall function.

Main Methods:

  • Literature review of recent discoveries in DNA modifications.
  • Analysis of DNA modification profiles in the mammalian brain.
  • Synthesis of current understanding on the roles of DNA modifications in brain processes.

Main Results:

  • DNA modifications, particularly methylation, are critical for diverse biological processes.
  • Specific patterns of DNA modifications exist within the mammalian brain genome.
  • These modifications are integral to neurodevelopment and neuronal function.

Conclusions:

  • DNA modifications are vital epigenetic regulators with significant roles in the mammalian brain.
  • Understanding these modifications is key to deciphering brain development and function.
  • Further research into DNA modifications promises insights into neurological processes and diseases.