Related Experiment Video

Updated: Apr 25, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

20.1K

In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important

Aspasia Katragkou1, Matthew McCarthy1, Joseph Meletiadis2

  • 1Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Department of Medicine, Weil Cornell Medical Center of Cornell University, New York, New York, USA.

Antimicrobial Agents and Chemotherapy
|August 20, 2014
PubMed

Insights

This study explored the combination of isavuconazole and micafungin against invasive mold infections. Researchers found synergistic activity, suggesting a potential new treatment for aspergillosis.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive mold infections pose significant treatment challenges.
  • The antifungal isavuconazole is an extended-spectrum triazole.
  • Combination therapy for invasive molds remains understudied.

Purpose of the Study:

  • To investigate the in vitro synergistic activity of isavuconazole with echinocandins or amphotericin B.
  • To evaluate the combination's efficacy against key invasive mold species.

Main Methods:

  • In vitro combination studies were performed.
  • Isavuconazole was tested in combination with micafungin.
  • Activity was assessed against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae.

Main Results:

  • Isavuconazole and micafungin demonstrated synergistic activity.
  • Synergy was observed against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae.

Conclusions:

  • Isavuconazole combined with micafungin shows synergistic potential.
  • This combination warrants further investigation for treating invasive aspergillosis.

More Related Videos

A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms07:19

A 96 Well Microtiter Plate-based Method for Monitoring Formation and Antifungal Susceptibility Testing of Candida albicans Biofilms

Published on: October 21, 2010

45.2K
Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells09:27

Automation of Bio-Atomic Force Microscope Measurements on Hundreds of C. albicans Cells

Published on: April 2, 2021

3.3K

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
114
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
2.1K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.0K