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Genetic factors and manganese-induced neurotoxicity

Pan Chen1, Nancy Parmalee1, Michael Aschner1

  • 1Department of Molecular Pharmacology, Albert Einstein College of Medicine Bronx, NY, USA.

Frontiers in Genetics
|August 20, 2014
PubMed

Insights

High manganese (Mn) exposure can cause manganism, a neurological disease similar to Parkinson's disease (PD). Understanding Mn transport and its link to PD genes is crucial for potential treatments.

Area of Science:

  • Neuroscience
  • Toxicology
  • Genetics

Background:

  • Manganese (Mn) is an essential trace metal, but excessive levels lead to neurotoxicity and manganism.
  • Manganism exhibits significant physiological and cellular similarities to Parkinson's disease (PD).

Purpose of the Study:

  • To explore the relationship between manganese toxicity and Parkinson's disease.
  • To investigate the role of Mn transport mechanisms and associated genes in neurodegeneration.

Main Methods:

  • Review of existing literature on manganese metabolism and neurotoxicity.
  • Analysis of genetic links between manganese regulation and Parkinson's disease.

Main Results:

  • High manganese exposure is a risk factor for manganism, a condition mimicking PD.
  • Mutations in the Mn exporter SLC30A10 cause toxicity, affecting liver and neurological function.
  • Four PD-associated genes are implicated in regulating manganese toxicity.

Conclusions:

  • Manganese homeostasis is critical for preventing neurological dysfunction.
  • The identified links between manganese toxicity and PD genes offer new insights into PD pathogenesis.
  • Further research into Mn transport and its role in PD is warranted.
Keywords:
Parkinson’s diseasemanganesemanganismneurotoxicity

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