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Updated: Apr 25, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
BRCA-associated ovarian cancer: from molecular genetics to risk management
Giulia Girolimetti1, Anna Myriam Perrone2, Donatella Santini3
1Dipartimento di Scienze Mediche e Chirurgiche, Unità di Genetica Medica, Università di Bologna, Policlinico S. Orsola-Malpighi, Via Massarenti 9 [Pad. 11, 2° Piano], 40138 Bologna, Italy.
Abstract:
Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring the current knowledge on epidemiological and molecular aspects of BRCA-associated OC predisposition, on pathology and clinical behavior of OC occurring in BRCA mutation carriers, and on the available options for managing asymptomatic carriers.
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