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Paraneoplastic syndromes in rheumatology
Bernhard Manger1, Georg Schett1
1Department of Internal Medicine 3, University of Erlangen-Nuremberg, Ulmenweg 18, D-91054 Erlangen, Germany.
Nature Reviews. Rheumatology
|August 20, 2014
Summary
Diagnosing cancer is crucial for patients with musculoskeletal symptoms, as tumors can cause rheumatic diseases. Early recognition by rheumatologists aids in timely malignancy diagnosis and treatment.
Area of Science:
- Rheumatology
- Oncology
- Molecular Biology
Background:
- Musculoskeletal symptoms often prompt rheumatic disease diagnosis.
- Tumors are an important, yet sometimes overlooked, cause of musculoskeletal conditions.
- Paraneoplastic rheumatic diseases require specific clinical recognition.
Purpose of the Study:
- To highlight the significance of tumors as a cause of rheumatic diseases.
- To emphasize the role of rheumatologists in diagnosing malignancy.
- To explore the molecular mechanisms linking tumors and musculoskeletal tissue alteration.
Main Methods:
- Clinical investigation of musculoskeletal syndromes.
- Review of tumor-related rheumatic disease presentations.
- Analysis of molecular mediators involved in tumor-induced tissue changes.
Main Results:
- Specific tumor entities are associated with distinct musculoskeletal syndromes.
- Tumors can selectively affect periosteum, synovium, fascia, muscles, and bones.
- Molecular mediators like VEGF and FGF23 play roles in these alterations.
Conclusions:
- Rheumatologists play a critical role in identifying malignancies presenting as rheumatic diseases.
- Understanding tumor-musculoskeletal interactions is key for diagnosis and treatment.
- Further research into molecular mechanisms can improve patient outcomes.
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