Related Experiment Video
Updated: Apr 25, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Pertussis: still a cause of death, seven decades into vaccination
Andrea Jakinovich1, Sunil K Sood
1aCohen Children's Medical Center of New York bSouthside Hospital of North Shore-LIJ Health System cHofstra North Shore-LIJ School of Medicine, New York, USA.
Purpose Of Review:
We review the resurgence of pertussis, including recent trends in epidemiology and reasons for the resurgence, as well as updated vaccination schedules and recommendations.
Recent Findings:
There has been a resurgence of pertussis in recent decades, in the United States and worldwide. This is a preventable cause of hospitalizations and deaths, especially among the infant population. Possible reasons for the resurgence include increased awareness via surveillance and reporting, diagnostic testing improvements, infant susceptibility coupled with exposure to infected caregivers, waning immunity despite complete vaccination, inferior long-term efficacy of acellular vaccines compared with whole-cell vaccines, circulating mutant strains of the bacterium, and parents refusing vaccination of their children. Progressively updated vaccine recommendations should be adhered to, as this is currently the only available tool to stem the public health challenge.
Summary:
The resurgence of pertussis is a multifaceted problem, but the implementation of immunization for all age groups is of utmost importance.
More Related Videos
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
06:32Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Related Concept Videos
Vaccinations
Diphtheria
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
History of Microbiology