Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Signal Sequences and Sorting Receptors

Signal Sequences and Sorting Receptors

Signal sequences are short amino acid sequences that guide newly synthesized proteins to their proper location within the cell. Classical signal sequences are fifteen to sixty amino acids long and present at the N-terminus of a polypeptide chain. Each signal sequence has a conserved segment of basic residues towards their N terminus, a hydrophobic core, and a C-terminus rich in polar residues. The C-terminus also contains a signal cleavage site and features a -3 -1 sequence motif. The -3-1...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Regeneration in planarians modifies behavioral switching.

iScience·2025

Same author

Planarian fragments behave as whole animals.

Current biology : CB·2022

Same author

Head removal enhances planarian electrotaxis.

The Journal of experimental biology·2022

Same author

Planarian fragments behave as whole animals.

Current biology : CB·2021

Same author

Thermal tolerance and routine oxygen consumption of convict cichlid, Archocentrus nigrofasciatus, acclimated to constant temperatures (20 °C and 30 °C) and a daily temperature cycle (20 °C → 30 °C).

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2021

Same author

Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits.

eLife·2021

Same journal

A global response contributes to tissue size robustness upon local induction of apoptosis.

Current biology : CB·2026

Same journal

Prebilaterian origin of monoaminergic signaling.

Current biology : CB·2026

Same journal

CLASP-dependent microtubule stabilization generates microtubule-based protrusive forces during Drosophila epithelial morphogenesis.

Current biology : CB·2026

Same journal

Pigeons make slow, divergent eye movements during flight and large, convergent eye movements when landing.

Current biology : CB·2026

Same journal

Temperature signals drive grass secondary cell wall thickening.

Current biology : CB·2026

Same journal

Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.

Current biology : CB·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

Published on: November 17, 2023

Behavioral sequencing: competitive queuing in the fly CNS.

William B Kristan¹

¹Section of Neurobiology, Division of Biological Sciences, UC San Diego, La Jolla, CA 92093-0357, USA.

Current Biology : CB

|August 20, 2014

Summary

This summary is machine-generated.

This study reveals how fruit flies (Drosophila) generate complex behaviors through sequenced motor acts. The findings suggest a common neuronal mechanism underlying complex motor pattern generation in animals.

More Related Videos

Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer

Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer

Published on: August 20, 2016

High-resolution Quantification of Odor-guided Behavior in Drosophila melanogaster Using the Flywalk Paradigm

High-resolution Quantification of Odor-guided Behavior in Drosophila melanogaster Using the Flywalk Paradigm

Published on: December 11, 2015

Related Experiment Videos

Last Updated: Apr 25, 2026

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

Published on: November 17, 2023

Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer

Olfactory Behaviors Assayed by Computer Tracking Of Drosophila in a Four-quadrant Olfactometer

Published on: August 20, 2016

High-resolution Quantification of Odor-guided Behavior in Drosophila melanogaster Using the Flywalk Paradigm

High-resolution Quantification of Odor-guided Behavior in Drosophila melanogaster Using the Flywalk Paradigm

Published on: December 11, 2015

Area of Science:

Neuroscience
Animal Behavior
Computational Biology

Background:

Animals exhibit complex motor patterns during behaviors like grooming.
Understanding the neuronal basis of these patterns is crucial for neuroscience.

Purpose of the Study:

To investigate the neuronal mechanisms underlying the sequential organization of motor acts in Drosophila grooming.
To determine if this mechanism is conserved across different nervous systems.

Main Methods:

Observational studies of Drosophila grooming.
Analysis of motor act sequencing.
Neuronal pathway mapping (inferred).

Main Results:

Identified a neuronal mechanism coordinating sequential motor acts.
Demonstrated that complex grooming patterns arise from ordered interactions of motor modules.
This mechanism may be conserved in other nervous systems.

Conclusions:

The study proposes a generalizable neuronal framework for generating complex motor sequences.
This framework sheds light on the evolution and control of motor behaviors in the animal kingdom.