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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
An online version of the Mooney Face Test: phenotypic and genetic associations
Roeland J Verhallen1, Jenny M Bosten1, Patrick T Goodbourn2
1Department of Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom.
Abstract:
The Mooney Face Test is a widely used test of face perception, but was originally designed to be administered by personal interview. We have developed a three-alternative forced-choice version for online testing. We tested 397 healthy adults between the ages of 18 and 42 (M=24 years). There was a wide range of performance (64-100% correct; M=89.6%). We observed a significant sex difference favoring males (.31 standard deviation; p =.004). In addition, independently of sex, higher 2D:4D digit ratios were significantly associated with higher scores (ρ=.14, p=.006). A genome-wide association study (GWAS) for a subset of 370 participants identified an association between Mooney performance and a polymorphism in the RAPGEF5 gene (rs1522280; p=9.68×10(-8)). This association survives a permutation test (p=.031).
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