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Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients
J J Ohisalo1, H L Vikman, S Ranta
1Department of Medical Chemistry, University of Helsinki, Finland.
The Biochemical Journal
|November 15, 1989
Abstract:
Changes in the amounts and functions of G-proteins have been reported in diabetic rats. We determined the Gi/Gs ratio of adipocyte plasma membranes in six insulinopenic diabetic patients and matched controls by immunoblotting with antisera against synthetic peptides corresponding to regions of G-proteins. No consistent changes in the Gi/Gs ratio were observed. It is still possible that the functional status of the G-proteins may be altered in diabetes.