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The cost-effectiveness of infliximab in Crohn's disease

Claire Smart1, Christian P Selinger

  • 1Gastroenterology, Leeds Teaching Hospitals NHS Trust, Beckett Lane, Leeds, LS9 7TF, UK.

Expert Review of Pharmacoeconomics & Outcomes Research
|August 21, 2014
PubMed

Insights

Infliximab effectively treats Crohn

Area of Science:

  • Gastroenterology
  • Pharmacoeconomics
  • Immunology

Background:

  • Crohn's disease (CD) is a chronic gastrointestinal inflammatory condition impacting quality of life.
  • Infliximab, a TNF-α inhibitor, is a recognized treatment for moderate to severe CD.
  • While costly, infliximab may reduce long-term healthcare utilization.

Purpose of the Study:

  • To review the cost-effectiveness of infliximab for Crohn's disease treatment.
  • To synthesize evidence regarding infliximab's economic value in CD management.

Main Methods:

  • Systematic review of existing studies on infliximab cost-effectiveness in CD.
  • Analysis of heterogeneous data considering varying settings, costs, and clinical outcomes.

Main Results:

  • Evidence for cost-effectiveness is highly variable due to study heterogeneity.
  • In the UK, infliximab was found to be cost-effective.
  • The estimated cost was approximately £25,000 per Quality Adjusted Life Year (QALY) gained.

Conclusions:

  • Infliximab can be a cost-effective treatment option for Crohn's disease.
  • Further research is needed to address heterogeneity in cost-effectiveness studies.
  • Economic evaluations should consider long-term benefits like reduced hospitalizations and surgeries.

Keywords:
Crohn's diseasecostcost–effectivenessinflammatory bowel diseaseinfliximab

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