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Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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Targeting TRP channels for novel migraine therapeutics
Gregory Dussor1, J Yan, Jennifer Y Xie
1School of Behavioral and Brain Sciences, University of Texas at Dallas , Dallas, Texas 75080, United States.
ACS Chemical Neuroscience
|August 21, 2014
Summary
Transient receptor potential (TRP) channels in the brain are activated by triggers, leading to migraine pain. Blocking TRP channel activation offers a new therapeutic strategy for migraine treatment.
Area of Science:
- Neuroscience
- Pain Research
- Pharmacology
Background:
- Migraine is a complex brain disorder involving trigeminal nerve activation.
- Trigeminal system sensitization leads to migraine pain and allodynia.
- Transient receptor potential (TRP) channels are implicated in migraine pathophysiology.
Purpose of the Study:
- To explore the role of TRP channels in migraine.
- To investigate TRP channel activation by various stimuli.
- To identify novel therapeutic targets for migraine.
Main Methods:
- Review of current understanding of TRP channels in trigeminovascular system.
- Analysis of TRP channel activation by endogenous and exogenous factors.
- Examination of the link between TRP channels, CGRP release, and migraine.
Main Results:
- TRP channels are expressed in dural afferents and activated by various stimuli.
- TRP channel activation leads to excitation of nociceptive fibers and CGRP release.
- Migraine triggers can activate TRP channels, contributing to pain and allodynia.
Conclusions:
- TRP channels are key players in migraine pathogenesis.
- Targeting TRP channel activation presents a promising therapeutic avenue.
- Preventing TRP channel activation could lead to novel migraine treatments.
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