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Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
23.8K
Robotic-assisted fluorescence sentinel lymph node mapping using multimodal image guidance in an animal model
Michael A Liss1, Sean P Stroup2, Zhengtao Qin3
1Department of Urology, UC San Diego Health System, San Diego, CA; UCSD Moores Cancer Center, La Jolla, CA.
Urology
|August 21, 2014
Summary
Preoperative PET/CT imaging accurately identified sentinel lymph nodes (SLNs) for prostate cancer surgery. Intraoperative fluorescence confirmed these SLNs, enabling precise robotic-assisted dissection.
Area of Science:
- Oncology
- Nuclear Medicine
- Surgical Innovation
Background:
- Sentinel lymph node (SLN) biopsy is crucial for accurate prostate cancer staging.
- Preoperative imaging combined with intraoperative detection can improve SLN identification accuracy.
Purpose of the Study:
- To evaluate the efficacy of a fluorescent-labeled radiopharmaceutical for preoperative PET/CT imaging and intraoperative detection of SLNs in a prostate cancer model.
- To assess the correlation between PET/CT findings and intraoperative fluorescence in identifying SLNs.
Main Methods:
- Beagle dogs received intraprostatic injection of fluorescent-tagged tilmanocept labeled with Ga-68 and Tc-99m.
- Preoperative pelvic PET/CT scans were performed for SLN mapping.
- Robotic-assisted SLN dissection was conducted using a fluorescence-capable camera system.
Main Results:
- PET/CT imaging successfully identified a median of 3 SLNs per animal.
- 100% of PET/CT-identified SLNs showed fluorescence during surgery.
- 75% of visualized fluorescent nodes met the PET/CT-defined SLN criteria.
Conclusions:
- Fluorescent-labeled tilmanocept demonstrates excellent properties for preoperative PET/CT imaging.
- This approach allows for real-time intraoperative confirmation during robotic-assisted SLN dissection.
- The combined imaging and intraoperative detection strategy enhances SLN identification in prostate cancer.
