Related Experiment Video

Updated: Apr 25, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

14.5K

Axl kinase as a key target for oncology: focus on small molecule inhibitors

Clémence Feneyrolles1, Aurélia Spenlinhauer1, Léa Guiet1

  • 1OriBase Pharma, Cap Gamma, Montpellier, France.

Molecular Cancer Therapeutics
|August 21, 2014
PubMed

Insights

Axl receptor tyrosine kinase (RTK) is implicated in cancer progression and therapy resistance. This review explores Axl

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • Receptor tyrosine kinases (RTKs) are crucial transmembrane proteins regulating cellular signal transduction.
  • The TAM (Tyro-3, Axl, Mer) subfamily RTKs, particularly Axl, play significant roles in cell growth, migration, aggregation, and apoptosis.
  • Axl overexpression/overactivation is linked to various cancers and contributes to resistance against chemotherapy and targeted therapies.

Purpose of the Study:

  • To highlight the therapeutic implications of Axl as a target in cancer treatment.
  • To review the signaling pathways regulated by Axl.
  • To define available tools and strategies for Axl inhibition.

Main Methods:

  • Literature review focusing on Axl signaling pathways.
  • Analysis of Axl's role in cancer and therapy resistance.
  • Examination of small molecule inhibitors targeting Axl.

Main Results:

  • Axl regulates critical cellular processes and its dysregulation is associated with oncogenesis.
  • Axl inhibition presents a promising therapeutic strategy for overcoming treatment resistance.
  • Various small molecule inhibitors targeting Axl have been developed with diverse structures and inhibition profiles.

Conclusions:

  • Axl is a validated therapeutic target in oncology due to its role in cancer progression and drug resistance.
  • Small molecule inhibitors targeting Axl are under active development, offering potential new treatment avenues.
  • Further research into Axl inhibition strategies is warranted to improve cancer therapy outcomes.

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

945
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

7.7K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.4K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.4K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.3K