[Changes in interleukin-1 and interleukin-2 in scalded rats]

The function of lymphocytes and macrophages after a 20% full-thickness scald injuries in a rat model was observed. After injuries, no significant change was found in phagocytic activity of macrophage. The interleukin 1 (IL-1) activity increased on 1th, 3th, 5th day (P less than 0.05) as compared with control. This result showed that the function of phagocytosis in macrophage is different from secretion. Lymphocyte proliferation decreased in ConA stimulated on 3th day after injury, the interleukin 2 (IL-2) activity decreased significantly on all days (12hr-5th day) (P less than 0.01). These might be related to the decrease of IL-2 and the decrease of immune function after burn injury.