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The Rh-negative donor.

M Contreras1, R C Knight

  • 1North London Blood Transfusion Centre, Colindale, London.

Clinical and Laboratory Haematology
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Rh blood group typing has been optimized. A new strategy for donor screening focuses on C, D, and E antigens, reducing unnecessary Du testing for D-negative, C-negative, and E-negative donations.

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Area of Science:

  • Transfusion Medicine
  • Immunology
  • Genetics

Background:

  • The Rh blood group system is crucial for transfusion compatibility.
  • Accurate Rh typing of blood donations is essential to prevent alloimmunization.
  • Previous Rh typing methods were resource-intensive and could be streamlined.

Purpose of the Study:

  • To evaluate the incidence of specific Rh antigen combinations in donor samples.
  • To develop a more efficient and cost-effective strategy for routine Rh blood typing of donations.
  • To refine donor categorization based on RhD antigen expression.

Main Methods:

  • Utilized the Kontron Groupamatic G2000 for initial Rh antigen typing (C, D, E).
  • Employed antiglobulin techniques for confirmatory Du testing on selected samples.

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  • Implemented a revised protocol for routine Rh typing, prioritizing C, D, and E antigen screening.

    • Main Results:

    • Identified incidences of Ccddee (r'r) at 0.44%, ccddEe (r"r) at 0.50%, and Du at 0.30% among D-negative, C-positive, and/or E-positive samples.
    • Found no positive Du results in 15,000 samples initially typed as D-, C-, and E-negative.
    • Established a new routine typing strategy that omits routine Du testing for D-, C-, and E-negative donations.

    Conclusions:

    • The revised Rh typing strategy is more efficient by reducing unnecessary Du testing.
    • Focusing on C, D, and E antigens provides adequate Rh typing for most donations.
    • Updated terminology for RhD-positive donors is recommended, excluding rare Category VI donors.