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Association between peripheral arterial disease and C-reactive protein in the Japanese-Brazilian population

Luciana Garofolo1, Sandra Roberta G Ferreira2, Fausto Miranda Júnior3

  • 1Unversidade Federal de São Paulo, São Paulo, Brazil.

Revista Do Colegio Brasileiro De Cirurgioes
|August 21, 2014
PubMed

Insights

Peripheral arterial disease (PAD) was not associated with elevated C-reactive protein in Japanese-Brazilians. However, lower ankle-brachial index values correlated with higher C-reactive protein, indicating greater cardiovascular risk.

Area of Science:

  • Cardiovascular Health
  • Epidemiology
  • Biomarkers

Background:

  • Peripheral arterial disease (PAD) is a significant indicator of systemic atherosclerosis.
  • C-reactive protein (CRP) is a marker of inflammation and cardiovascular risk.
  • Understanding the relationship between PAD and CRP in diverse populations is crucial for risk stratification.

Purpose of the Study:

  • To investigate the association between peripheral arterial disease (PAD) and ultrasensitive C-reactive protein (us-CRP) levels.
  • To assess cardiovascular risk factors in the Japanese-Brazilian population.

Main Methods:

  • Cross-sectional study of 1,038 Japanese-Brazilian adults (aged ≥30).
  • Diagnosis of PAD based on ankle-brachial index (ABI) ≤ 0.9.
  • Measurement of ultrasensitive C-reactive protein (us-CRP) levels.

Main Results:

  • Prevalence of PAD was 21%, with no gender difference.
  • No significant association found between PAD and us-CRP levels.
  • Lower ABI (≤ 0.70) correlated with higher us-CRP and poorer cardiometabolic profiles.
  • PAD independently associated with hypertension and smoking.

Conclusions:

  • While PAD and us-CRP were not directly associated, low ABI values indicate elevated inflammation and risk.
  • The findings suggest that ABI severity, rather than PAD presence alone, may correlate with inflammation.
  • This highlights the importance of ABI in identifying high-risk individuals.
Abstract

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