Related Experiment Video
Updated: Apr 25, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Reconstructing fungal natural product biosynthetic pathways
C M Lazarus1, K Williams, A M Bailey
1School of Biological Sciences, University of Bristol, Bristol Life Sciences Building, 24 Tyndall Avenue, Bristol, BS8 1TQ, UK. c.m.lazarus@bristol.ac.uk.
Abstract:
Large scale fungal genome sequencing has revealed a multitude of potential natural product biosynthetic pathways that remain uncharted. Here we describe some of the methods that have been used to explore them via heterologous gene expression. We focus on filamentous fungal hosts and discuss the technological challenges and successes behind the reconstruction of fungal natural product pathways. Optimised, efficient heterologous expression of reconstructed biosynthetic pathways promises progress in the discovery of novel compounds that could be utilised by the pharmaceutical and agrochemical industries.
Related Concept Videos
Amino Acid Biosynthetic Pathways
Production of Antibiotics
Bioreactor Controls-III
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Biosynthesis in Bacteria
Biosynthesis of Lipids

