Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

68
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
68
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Exercise Stress Test01:26

Exercise Stress Test

2.2K
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sleep disturbance and brain health in professional association footballers.

Frontiers in sports and active living·2026
Same author

Are exercise booster sessions effective at preserving exercise-induced effects in people with multiple sclerosis? A randomised controlled trial: results from the MSBOOST trial.

Journal of science and medicine in sport·2026
Same author

Adrenaline for traumatic cardiac arrest: A post hoc analysis of the PARAMEDIC2 trial.

Resuscitation plus·2025
Same author

The accuracy of prehospital triage decisions in English trauma networks - a case-cohort study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2024
Same author

The impact of musculoskeletal ill health on quality of life and function after critical care: a multicentre prospective cohort study.

Anaesthesia·2024
Same author

A feasibility study to determine whether the daily consumption of flavonoid-rich pure cocoa has the potential to reduce fatigue and fatigability in people with Parkinson's (pwP).

Clinical nutrition ESPEN·2022

Related Experiment Video

Updated: Apr 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.4K

Exercise testing and training in people with Huntington's disease.

H Dawes1, J Collett2, K Debono3

  • 1Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, UK Department of Clinical Neurology University of Oxford, UK hdawes@brookes.ac.uk.

Clinical Rehabilitation
|August 22, 2014
PubMed
Summary
This summary is machine-generated.

People with Huntington's disease (HD) showed lower work rates and higher perceived exertion during exercise compared to healthy individuals. Further research is needed to understand and optimize exercise prescriptions for HD patients.

Keywords:
Exercise testingHuntington’s diseaseaerobic exerciseexercise response

More Related Videos

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

2.2K
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

12.2K

Related Experiment Videos

Last Updated: Apr 25, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

20.4K
Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System
02:47

Author Spotlight: Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

Published on: May 12, 2023

2.2K
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

12.2K

Area of Science:

  • Neurology
  • Exercise Physiology
  • Human Physiology

Background:

  • Huntington's disease (HD) is a progressive neurodegenerative disorder affecting motor, cognitive, and behavioral functions.
  • Understanding the physiological responses to exercise in individuals with HD is crucial for developing effective rehabilitation strategies.
  • Current exercise guidelines for HD may not fully account for the unique physiological challenges faced by this population.

Purpose of the Study:

  • To investigate the exercise response in individuals diagnosed with Huntington's disease (HD).
  • To compare the physiological and metabolic responses to a standardized exercise test between people with HD and a healthy control group.
  • To evaluate the impact of a structured exercise intervention on exercise response in a subgroup of individuals with HD.

Main Methods:

  • An experimental observational study design was employed, including a randomized subgroup for a before/after intervention.
  • Participants included 30 individuals with HD and 20 healthy controls, with 13 individuals with HD undergoing a 12-week exercise program.
  • Submaximal cycle ergometer tests measured heart rate (HR), perceived exertion (Borg-CR10 scale), and metabolic markers (lactate, respiratory exchange ratio).

Main Results:

  • Individuals with HD exhibited a lower work rate and significantly higher perceived exertion at multiple time points during the exercise test compared to controls.
  • People with HD demonstrated elevated lactate levels and respiratory exchange ratios, indicating altered metabolic and cardiorespiratory responses.
  • No significant changes in heart rate or perceived exertion were observed after the 12-week exercise intervention in the HD subgroup.

Conclusions:

  • Significant variability exists in metabolic and physiological responses to exercise among individuals with Huntington's disease.
  • The findings suggest that current exercise prescription parameters may need modification for people with HD.
  • Further investigation is warranted to fully understand exercise responses and influencing factors in the HD population to guide tailored interventions.