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Chlorambucil-induced cytomegalovirus infection: a case report
María Thiscal López-Lluva1, María Dolores Sanchez de la Nieta-García, Jesús Piqueras-Flores
1Servicio de Cardiología, Hospital General Universitario de Ciudad Real, Calle del Obispo Rafael Torija s/n, 13005 Ciudad Real, España. mtl.lluva@gmail.com.
Introduction:
Chlorambucil is an alkylating agent used in combination with prednisolone for the treatment of idiopathic membranous nephropathy. Although chlorambucil is generally well-tolerated, it is a myelosuppresive drug that can cause several infections.
Case Presentation:
We report the case of an 81-year-old Caucasian male presenting with idiopathic membranous nephropathy who developed fever, cough, dyspnea, pulmonary infiltrates, and abdominal pain shortly after the initiation of treatment with chlorambucil and corticosteroids for nephropathy. Virology tests for infectious diseases revealed a recent cytomegalovirus infection. Antiviral treatment (ganciclovir) resulted in full remission.
Conclusions:
Cytomegalovirus infection should be considered in the differential diagnosis of respiratory symptoms and pulmonary infiltrates in patients treated with chlorambucil for nephrotic syndrome.
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