Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

1.0K
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

750
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
750
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

643
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
643
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

751
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
751

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The use of diuretics in heart failure with congestion - a position statement from the Heart Failure Association of the European Society of Cardiology.

European journal of heart failure·2019
Same author

Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome.

mBio·2018
Same author

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.

The Journal of clinical investigation·2018
Same author

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women.

European heart journal·2018
Same author

High-sensitivity troponin T, NT-proBNP and glomerular filtration rate: A multimarker strategy for risk stratification in chronic heart failure.

International journal of cardiology·2018
Same author

Dietary metabolism, the gut microbiome, and heart failure.

Nature reviews. Cardiology·2018

Related Experiment Video

Updated: Apr 25, 2026

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes
13:42

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes

Published on: March 8, 2013

11.4K

Autoantibodies and cardiovascular dysfunction: cause or consequence?

Yuji Nagatomo1, W H Wilson Tang

  • 1Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Current Heart Failure Reports
|August 22, 2014
PubMed
Summary
This summary is machine-generated.

Autoantibodies (AAbs) may play a role in cardiovascular diseases like dilated cardiomyopathy (DCM). Research suggests AAbs could be a therapeutic target for treating DCM and related conditions.

More Related Videos

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.7K
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

140.3K

Related Experiment Videos

Last Updated: Apr 25, 2026

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes
13:42

Measurement of Antibody Effects on Cellular Function of Isolated Cardiomyocytes

Published on: March 8, 2013

11.4K
Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
12:46

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells

Published on: August 17, 2022

2.7K
Anti-Nuclear Antibody Screening Using HEp-2 Cells
13:01

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

140.3K

Area of Science:

  • Cardiology
  • Immunology
  • Pathology

Background:

  • Autoimmunity is explored as a cause of idiopathic cardiovascular diseases, particularly dilated cardiomyopathy (DCM).
  • Autoantibodies (AAbs) arise from tissue damage or immune dysregulation and are implicated in DCM pathogenesis.
  • The role of IgG3 subclass autoantibodies in cardiovascular pathology is gaining attention.

Purpose of the Study:

  • To review current findings on autoantibodies involved in dilated cardiomyopathy (DCM) and pregnancy-related cardiovascular disease.
  • To discuss the significance of autoantibodies as a potential cause of DCM.
  • To explore autoantibodies as novel therapeutic targets for cardiovascular diseases.

Main Methods:

  • Review of basic research (in vitro, in vivo models) and clinical studies.
  • Analysis of immunoadsorption studies in DCM patients.
  • Synthesis of accumulated evidence on autoantibodies in cardiovascular pathology.

Main Results:

  • Evidence suggests autoantibodies contribute to the pathology of DCM.
  • Specific autoantibodies, including IgG3 subclass, are implicated in cardiovascular disease.
  • Immunoadsorption studies support the pathogenic role of autoantibodies in DCM.

Conclusions:

  • Autoantibodies are significant factors in the pathogenesis of dilated cardiomyopathy (DCM).
  • Autoantibodies represent a potential novel therapeutic target for cardiovascular diseases.
  • Further research into autoantibodies may elucidate causes and treatments for DCM.