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Modulation of metabolizing enzymes by bisphenol a in human and animal models

Nicolas Quesnot1, Simon Bucher, Bernard Fromenty

  • 1INSERM, UMR 991, F-35033 Rennes, France.

Chemical Research in Toxicology
|August 22, 2014
PubMed

Insights

Bisphenol A (BPA) affects drug and contaminant metabolism by altering key enzymes and transporters. Even at low doses, BPA can impact these critical cellular processes, influencing toxicity.

Area of Science:

  • Environmental Toxicology
  • Pharmacology
  • Biochemistry

Background:

  • Xenobiotics are processed by phase 1, 2, and 3 enzymes and transporters.
  • These processes can be modulated by xenobiotics, affecting toxicity.
  • Bisphenol A (BPA) is a widespread contaminant with xenoestrogen properties.

Purpose of the Study:

  • To review the impact of Bisphenol A (BPA) on xenobiotic metabolizing enzymes and transporters.
  • To highlight BPA's modulation of cytochromes P450 involved in steroid metabolism.

Main Methods:

  • Literature review of studies on Bisphenol A (BPA) and xenobiotic metabolism.
  • Analysis of BPA's effects on major enzyme classes (CYP450, GST, SULT, UGT) and transporters.
  • Focus on studies reporting enzyme induction or inhibition.

Main Results:

  • Bisphenol A (BPA) impacts major xenobiotic metabolizing enzymes and transporters.
  • BPA modulates cytochromes P450, particularly those in steroid metabolism.
  • Enzyme modulation by BPA occurs at both high and low (human-relevant) exposure doses.

Conclusions:

  • Bisphenol A (BPA) significantly affects xenobiotic metabolism and elimination pathways.
  • BPA's ability to alter enzyme activity at low doses raises concerns for human health.
  • Further research is needed to understand the full toxicological implications of BPA exposure.

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