Reassessment of genotype 1 hepatitis C virus subtype misclassification by LiPA 2.0: implications for direct-acting antiviral treatment
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Javier R Guelfo1, Juan Macias1, Karin Neukam1
1Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Seville, Spain Instituto de Biomedicina de Seville (IBIS), Seville, Spain.
Journal of Clinical Microbiology
|August 22, 2014
Abstract:
The accuracy of LiPA 2.0 for hepatitis C virus 1 (HCV-1) subtype classification was analyzed. LiPA 2.0 genotype results from 101 HCV-1-infected patients were compared to genotype findings determined by direct core sequencing. Eleven (11%) samples were misclassified. Given the influence of the HCV-1-subtype in the anti-HCV therapy response, an alternative classification method is warranted.
