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Oestrogen, ocular function and low-level vision: a review.

Claire V Hutchinson1, James A Walker2, Colin Davidson2

  • 1College of MedicineBiological Sciences and Psychology, University of Leicester, Leicester LE1 9HN, UKHarvard Medical SchoolCenter for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USADivision of Biomedical SciencesSt George's Medical School, University of London, London SW17 0RE, UK ch190@le.ac.uk.

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Summary
This summary is machine-generated.

Oestrogen significantly impacts vision and eye health, especially in older women. This review explores oestrogen

Keywords:
eyemenopauseoestrogenvision

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Area of Science:

  • Ophthalmology and Endocrinology
  • Neuroscience and Vision Science

Background:

  • Emerging research highlights the role of the sex steroid hormone oestrogen in human vision.
  • Oestrogen (oestradiol) levels may significantly affect ocular function and visual acuity, particularly in aging females.

Purpose of the Study:

  • To review the evidence linking oestrogen levels to various vision-related disorders.
  • To discuss the impact of oestrogen-related therapies on eye health and visual perception.
  • To explore potential mechanisms of oestrogen's beneficial effects on vision.

Main Methods:

  • Systematic literature review of studies published over the past 10 years.
  • Analysis of research on oestrogen's influence on conditions such as dry eye, cataract, glaucoma, and macular degeneration.
  • Examination of pharmacological treatments for menopause and breast cancer and their ocular side effects.

Main Results:

  • Oestrogen, or its deficiency, plays a role in numerous vision disorders.
  • Hormone replacement therapies and cancer treatments can affect ocular pathology and vision.
  • Oestrogen exhibits potential beneficial effects through anti-apoptotic and vascular mechanisms.

Conclusions:

  • Oestrogen is a critical factor in maintaining ocular health and visual function.
  • Understanding oestrogen's role can inform therapeutic strategies for vision impairment in women.
  • Further research into oestrogen's pharmacology is warranted to elucidate its protective effects on the eye.