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G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease

Matthew J Billard1, Bryan J Gall2, Kristy L Richards3

  • 1Thurston Arthritis Research Center and The Department of Medicine, Division of Rheumatology, Allergy, and Immunology, University of North Carolina Chapel Hill, NC 27599, USA.

American Journal of Clinical and Experimental Immunology
|August 22, 2014
PubMed

Insights

G protein signaling modulator-3 (GPSM3) regulates immune cell signaling by interacting with G proteins. Genetic variations in GPSM3 are linked to chronic inflammatory diseases, highlighting its role in immunity.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Signaling

Background:

  • G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a protein featuring the GoLoco motif.
  • It interacts with Gα and Gβ subunits of heterotrimeric G proteins.
  • GPSM3 regulates intracellular signals downstream of G protein-coupled receptors (GPCRs).

Purpose of the Study:

  • To review the current understanding of GPSM3 function.
  • To explore GPSM3's role in normal and pathological immune conditions.
  • To connect GPSM3 genetic variations to chronic inflammatory diseases.

Main Methods:

  • Literature review of existing studies on GPSM3.
  • Analysis of G protein signaling pathways involving GPSM3.
  • Examination of genome-wide association studies (GWAS) data.

Main Results:

  • GPSM3 is highly expressed in immune system cells, indicating a specialized role.
  • Single nucleotide polymorphisms (SNPs) in GPSM3 are associated with chronic inflammatory diseases.
  • GPSM3's interaction with G proteins modulates immune responses.

Conclusions:

  • GPSM3 is a key regulator in immune cell signaling pathways.
  • Genetic variations in GPSM3 contribute to the susceptibility of chronic inflammatory diseases.
  • Further research into GPSM3 function is crucial for understanding and treating immune-mediated conditions.
Keywords:
G protein coupled receptorGPSM3GoLocochemokinemigrationrheumatoid arthritis

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