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Vitamin D and atherosclerosis.

Arthur R Menezes1, Marie C Lamb, Carl J Lavie

  • 1aDepartment of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School- The University of Queensland School of Medicine bDepartment of Preventive Cardiology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana cMid America Heart Institute, Kansas City, Missouri, USA.

Current Opinion in Cardiology
|August 22, 2014
PubMed
Summary
This summary is machine-generated.

Vitamin D deficiency is common and linked to atherosclerosis. Vitamin D plays a protective role against cardiovascular disease through various mechanisms.

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is a global health concern.
  • It is traditionally linked to bone health but increasingly associated with systemic diseases.
  • Emerging evidence suggests a connection between vitamin D deficiency and atherosclerosis.

Purpose of the Study:

  • To review the association between vitamin D deficiency and atherosclerosis.
  • To explore the mechanisms by which vitamin D influences cardiovascular health.

Main Methods:

  • Literature review of studies investigating vitamin D and atherosclerosis.
  • Analysis of proposed biological pathways and clinical observations.

Main Results:

  • Vitamin D demonstrates protective effects against atherosclerosis via multiple pathways.
  • Mechanisms include protection of endothelial function, regulation of vascular smooth muscle cells, and immune modulation.
  • Vitamin D also impacts systemic factors like insulin resistance, dyslipidemia, and hypertension.

Conclusions:

  • Vitamin D deficiency is prevalent worldwide and linked to atherosclerosis.
  • Vitamin D deficiency impacts multiple organ systems beyond musculoskeletal health.
  • Further research is warranted to understand the full clinical implications of vitamin D status on cardiovascular disease.