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Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.

Michaela Matthes¹, Martin Preusse¹, Jingzhong Zhang²

¹Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Technische Universität München-Weihenstephan, Lehrstuhl für Genetik, Emil-Ramannstr. 8, 85354 Freising, Germany, Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Technische Universität München, Zentrum Mathematik, Boltzmannstr. 3, 85747 Garching, Germany, Max-Planck-Institute of Psychiatry, Kraepelinstr. 2-10, 80804 München, Germany, Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE), Standort München, Schillerstr. 44, 80336 München, Germany, Technische Universität München-Weihenstephan, Lehrstuhl für Entwicklungsgenetik, c/o Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany and Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität München, Schillerstr. 44, 80336 München, Germany Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Technische Universität München-Weihenstephan, Lehrstuhl für Genetik, Emil-Ramannstr. 8, 85354 Freising, Germany, Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany, Technische Universität München, Zentrum Mathematik, Boltzmannstr. 3, 85747 Garching, Germany, Max-Planck-In

Database : the Journal of Biological Databases and Curation

|August 23, 2014

Summary

This summary is machine-generated.

Mouse IDGenes is a new database detailing genetic interactions in the developing mouse brain. It aids research into neurodevelopmental disorders by providing curated gene expression and interaction data.

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Area of Science:

Neuroscience
Developmental Biology
Bioinformatics

Background:

Understanding neural development is crucial for addressing human neuropsychiatric and neurodegenerative disorders.
Neural tube patterning involves complex gene expression and interactions, often overlooked in public databases.
Existing resources lack comprehensive data on genetic interactions governing brain development.

Purpose of the Study:

To introduce Mouse IDGenes, a curated database of genetic interactions in the developing mouse brain.
To provide a resource for studying gene expression and interactions in mid-/hindbrain development.
To demonstrate the utility of interaction data for predicting developmental pathways.

Main Methods:

Database curation of gene expression and genetic interactions.
Machine learning to infer Wnt/β-catenin target genes.
Experimental validation of predicted target genes.

Main Results:

Mouse IDGenes offers detailed, curated information on gene expression and interactions.
New Wnt/β-catenin target genes were predicted using machine learning.
One novel target gene was experimentally validated, showcasing the database's predictive power.

Conclusions:

Mouse IDGenes is a valuable resource for mouse brain development research.
The database facilitates data retrieval and community input for ongoing research.
Integrating genetic interaction data enhances understanding of neurodevelopmental processes.