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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

14
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
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Related Experiment Video

Updated: Apr 25, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

28.8K

Controlled cortical impact model for traumatic brain injury.

Jennifer Romine1, Xiang Gao1, Jinhui Chen2

  • 1Spinal Cord and Brain Injury Research Group, Stark Neuroscience Research Institute, Department of Neurological Surgery, Indiana University School of Medicine.

Journal of Visualized Experiments : Jove
|August 23, 2014
PubMed
Summary

Traumatic brain injury (TBI) affects millions globally. The controlled cortical impact (CCI) model offers a precise method to study TBI's effects and test new treatments.

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Last Updated: Apr 25, 2026

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Area of Science:

  • Neuroscience
  • Neurological Surgery
  • Biomedical Engineering

Background:

  • Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
  • Millions of Americans suffer TBI annually, with significant physical, emotional, social, and economic consequences.
  • Effective treatments and a deeper understanding of TBI pathology are crucial.

Purpose of the Study:

  • To introduce and detail the controlled cortical impact (CCI) model for inducing TBI.
  • To highlight the advantages of the CCI model over other TBI models.
  • To emphasize the CCI model's utility in investigating TBI's short- and long-term effects and potential therapies.

Main Methods:

  • The controlled cortical impact (CCI) model involves mechanical impact to the exposed dura mater.
  • A rigid impactor delivers controlled mechanical energy at a set velocity.
  • Precise parameters are used to achieve a predetermined deformation depth, inducing TBI.

Main Results:

  • The CCI model can induce a range of TBI severity, from mild to severe.
  • It offers greater accuracy and control compared to weight drop or fluid percussion models.
  • The CCI model produces injuries that closely mimic human TBI pathology.

Conclusions:

  • The CCI model is a valuable tool for studying the acute and chronic effects of TBI.
  • It facilitates research into neuronal death, memory deficits, and cerebral edema.
  • This model supports the development and testing of therapeutic interventions for TBI.