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Novel approaches to intraperitoneal drug delivery
S B Howell1, S Kirmani, R Goel
1Department of Medicine, University of California, San Diego La Jolla 92093.
Acta Medica Austriaca
|January 1, 1989
Abstract:
The prolonged continuous intraperitoneal infusion of cytoarabin was studied in 28 courses. Only 9 courses were completed for the full period of 3 weeks. No cytoarabin was detected in the plasma of patients on any of these courses. The combination of intraperitoneal administration of methotrexate and dipyridamole did not show a synergistic interaction of these 2 substances. However, the addition of dipyridamole to etoposide showed a clear synergy between these 2 substances studied on a human ovarian carcinoma cell line.