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Cingulum bundle alterations underlie subjective fatigue in multiple sclerosis.

Matteo Pardini1, Laura Bonzano1, Maurizio Bergamino1

  • 1Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Italy/Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 23, 2014
PubMed
Summary
This summary is machine-generated.

Subjective fatigue in multiple sclerosis (MS) is linked to structural damage in the brain's cingulum bundle. This study used MRI and a connectionist model to identify key brain networks involved in MS fatigue.

Keywords:
White mattercingulum bundlediffusion tensor imagingfatigue

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Subjective fatigue is a common and debilitating symptom in multiple sclerosis (MS).
  • The underlying neural mechanisms of MS-related fatigue are not fully understood.
  • A connectionist framework offers a novel approach to model complex neurological symptoms.

Purpose of the Study:

  • To investigate the neural basis of subjective fatigue in multiple sclerosis (MS) patients.
  • To utilize a connectionist framework to analyze brain connectivity related to fatigue.
  • To identify specific white matter pathways associated with fatigue severity in MS.

Main Methods:

  • Recruited 77 subjects with relapsing-remitting MS for subjective fatigue evaluations and diffusion MRI scans.
  • Correlated local white matter Fractional Anisotropy (FA) values with fatigue scores using voxel-wise analysis.
  • Assessed long-range connectivity loss using the Network Modification (NeMo) package.

Main Results:

  • Voxel-wise regression identified significant associations between structural damage and fatigue in two white matter clusters within the left cingulum bundle.
  • Connectivity analysis revealed that damage in these clusters correlated with lost structural connectivity in anterior/medial cingulate cortices, dorsolateral prefrontal areas, and the left caudate.
  • These findings highlight the cingulum bundle's role in fatigue perception.

Conclusions:

  • The cingulum bundle and its projections are identified as a key network in subjective fatigue perception in MS.
  • The connectionist framework shows potential for modeling the neural basis of complex MS symptoms.
  • This research provides insights into the neurobiological underpinnings of fatigue in multiple sclerosis.