Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

799
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
799
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

974
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
974
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.7K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.7K
Cancer Vaccines01:30

Cancer Vaccines

1.3K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.3K
Vaccinations01:51

Vaccinations

43.8K
Overview
43.8K
Vaccines01:21

Vaccines

86
Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the...
86

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluoroscopic evaluation of the cranial spread of contrast medium after sacrococcygeal or lumbosacral epidural injection in feline cadavers: a randomized noninferiority study.

Veterinary anaesthesia and analgesia·2026
Same author

Seasonal variations in mold identification in medical microbiology laboratories using MSI-2 application, France (2020-2024).

Medical mycology·2026
Same author

Synergistic impacts of heat, pollen, and air pollution on allergic rhinitis and asthma under climate change: A 20-year time-series study.

Environment international·2026
Same author

Patient safety investigative methods identify contributors to canine magnetic resonance imaging dermatologic thermal injuries in an academic hospital.

American journal of veterinary research·2026
Same author

Alveolar and Airway Components of the Tidal Volume in Mechanically Ventilated Dogs: An Exploratory Cross-Sectional Study.

Animals : an open access journal from MDPI·2026
Same author

Effects of Lidocaine Alone Versus Lidocaine-Dexmedetomidine Infusion on Pulmonary Gas Exchange and Respiratory Mechanics During Isoflurane Anesthesia in Horses.

Veterinary sciences·2025

Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

3.0K

DNA vaccines against tuberculosis.

Nicolas Bruffaerts1, Kris Huygen, Marta Romano

  • 1Scientific Institute of Public Health, O.D. CID-Immunology , Engelandstraat 642, Brussels, B1180 , Belgium kris.huygen@wiv-isp.be.

Expert Opinion on Biological Therapy
|August 23, 2014
PubMed
Summary

Novel DNA vaccines show promise for tuberculosis (TB) prevention, offering advantages over traditional methods. These vaccines can enhance immune responses and may be combined with existing vaccines for improved efficacy.

Keywords:
DNA vaccineprime-boost protocolstuberculosisvaccine

More Related Videos

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.9K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

9.8K

Related Experiment Videos

Last Updated: Apr 25, 2026

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis
06:26

Author Spotlight: Optimizing CFU Determination for Efficient Assessment of TB Vaccine Efficacy and Antigen Presentation Analysis

Published on: July 28, 2023

3.0K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.9K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

9.8K

Area of Science:

  • Immunology
  • Vaccinology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) poses a significant global health challenge, necessitating the development of new vaccination strategies.
  • Current vaccination approaches for TB require enhancement to provide broader and more effective protection.

Purpose of the Study:

  • To evaluate the potential of DNA vaccines as a novel approach for tuberculosis prevention.
  • To explore the use of DNA vaccines in prime-boost strategies with existing vaccines like bacillus Calmette-Guérin (BCG).

Main Methods:

  • Preclinical testing of DNA vaccines against TB in various models.
  • Development of strategies to improve DNA vaccine immunogenicity in large animal species.
  • Investigating the induction of CD8(+) T-cell-mediated immune responses, including interferon-gamma (IFN-γ) and cytolytic activity.

Main Results:

  • DNA vaccines can elicit diverse immune responses, including robust MHC class I-restricted cytotoxic T lymphocyte (CTL) activity.
  • DNA vaccination demonstrates potential for inducing memory responses, making it suitable for immune priming.
  • Heterologous prime-boost strategies using DNA vaccines with BCG could broaden the antigenic coverage and improve immune responses.

Conclusions:

  • DNA vaccines offer advantages such as generic manufacturing and cost-effectiveness.
  • The technology facilitates antigen discovery and screening for new vaccine candidates.
  • Co-administration of BCG with plasmid DNA encoding specific antigens may lead to improved TB vaccines.