Dearomative indole [5+2] cycloaddition reactions: stereoselective synthesis of highly functionalized
Guangjian Mei1, Hao Yuan, Yueqing Gu
1Laboratory of Chemical Genomics, School of Chemical Biology andBiotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055 (China).
Abstract:
The first dearomative indole [5+2] cycloaddition reaction with an oxidopyrylium ylide resulted in efficient and diastereoselective construction of some highly functionalized and synthetically challenging oxacyclohepta[b]indoles. The protocol proceeds under very mild reaction conditions, thus enabling high functional-group tolerance and unique endo selectivity.
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