Related Experiment Video
Updated: Aug 10, 2026

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
Published on: December 23, 2014
[Effect of cicletanine on prostacyclin generation in vivo]
R H Bourgain1, C Deby, R Andries
1Laboratoire de physiologie et de physiopathologie, VUB, Bruxelles, Belgique.
Abstract:
The administration of arachidonic acid to live rabbits if followed by the generation of prostacyclin and/or thromboxane. Cicletanine increased the production of prostacyclin in a first group of rabbits and amplified the prostacyclin/thromboxane ratio in a second group of the thromboxane type. The most probable mechanism for this action is activation of prostacyclin synthase by cicletanine. This was confirmed in the in vivo model by a study of the platelet-vascular wall interaction: tranylcyprominE, a prostacyclin synthase inhibitor, increased the interaction. Under these experimental conditions, cicletanine inhibited the effect of tranylcypromine and completely restored the enzymatic activity of prostacyclin synthase.
Related Concept Videos
Nitric Oxide Signaling Pathway
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

