Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Crystal Structures01:29

Determination of Crystal Structures

135
In the late 1800s, the revelation that light extended beyond visible wavelengths led to the discovery of X-rays by Wilhelm Roentgen. Recognized as high-energy electromagnetic radiation with short wavelengths, X-rays prompted exploration into their interaction with crystals. Max von Laue proposed in 1912 that the periodic arrangement of atoms, ions, or molecules in crystals would cause them to diffract X-rays, a hypothesis confirmed through experiments with copper sulfate and zinc sulfide...
135
High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

2.3K
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Joint EANM/SNMMI guideline on radiomics in nuclear medicine : Jointly supported by the EANM Physics Committee and the SNMMI Physics, Instrumentation and Data Sciences Council.

European journal of nuclear medicine and molecular imaging·2022
Same author

Osteoporosis identification among previously undiagnosed individuals with vertebral fractures.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Standardization in Quantitative Imaging: A Multicenter Comparison of Radiomic Features from Different Software Packages on Digital Reference Objects and Patient Data Sets.

Tomography (Ann Arbor, Mich.)·2020
Same author

Ambient temperature and solar insolation are associated with decreased prevalence of SSRI-treated psychiatric disorders.

Journal of psychiatric research·2018
Same author

Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project.

AJNR. American journal of neuroradiology·2018
Same author

Characterization of highly multiplexed monolithic PET / gamma camera detector modules.

Physics in medicine and biology·2018

Related Experiment Video

Updated: Apr 25, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

8.7K

Multiplexing strategies for monolithic crystal PET detector modules.

L A Pierce1, W C J Hunter, D R Haynor

  • 1Department of Radiology, University of Washington, Seattle, WA, USA.

Physics in Medicine and Biology
|August 23, 2014
PubMed
Summary

Researchers explored multiplexing strategies for Positron Emission Tomography (PET) detectors to cut costs. Principal component analysis (PCA) on calibration data offered a promising method for reducing output channels while maintaining excellent positioning resolution.

More Related Videos

Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry
09:15

Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry

Published on: July 26, 2019

8.9K
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
10:21

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

10.6K

Related Experiment Videos

Last Updated: Apr 25, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

8.7K
Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry
09:15

Optimization, Design and Avoiding Pitfalls in Manual Multiplex Fluorescent Immunohistochemistry

Published on: July 26, 2019

8.9K
Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
10:21

Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers

Published on: May 5, 2016

10.6K

Area of Science:

  • Medical Physics
  • Instrumentation
  • Nuclear Medicine

Background:

  • Reducing output channels in PET detectors is crucial for lowering costs.
  • Multiplexing strategies are investigated to achieve this reduction.
  • Optimizing these strategies is key for maintaining detector performance.

Purpose of the Study:

  • To identify an optimal signal multiplexing strategy for PET detector modules.
  • To evaluate data-driven methods, specifically principal component analysis (PCA), against traditional methods.
  • To assess the impact of multiplexing on detector positioning resolution and bias.

Main Methods:

  • Simulated multiplexing strategies were applied to measured data from LYSO scintillator coupled to 64-channel PMT detector modules.
  • Tested strategies included row-column summation and PCA-based methods.
  • Detector positioning resolution (FWHM) and bias were measured and compared for each strategy.

Main Results:

  • No multiplexing (64 channels) yielded a mean FWHM of 1.23 mm.
  • 16 principal component channels achieved a mean FWHM of 1.21 mm, outperforming row-column summation (1.28 mm).
  • 8 principal component channels resulted in a 1.30 mm FWHM resolution.

Conclusions:

  • Using principal components of calibration data for multiplexing is a viable strategy for reducing output channels in PET detectors.
  • This data-driven approach shows potential for cost reduction without significant loss in positioning resolution.
  • Further research is required to evaluate the impact on depth-of-interaction resolution.