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Updated: Apr 25, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
The current state of ototoxicity monitoring in New Zealand
Lotte Steffens1, Kinau Venter, Greg A O'Beirne
1c/- RMO Unit, Christchurch Hospital, Riccarton Ave, Private Bag 4710, Christchurch 8140, New Zealand. Lotte.Steffens@cdhb.health.nz.
Aim:
To explore medical oncologists' and audiologists' knowledge and attitudes regarding ototoxicity monitoring, and to gain an understanding of monitoring currently being implemented at District Health Boards (DHBs) nationwide. We also aimed to identify ways in which audiological outcomes for patients receiving potentially ototoxic treatments could be improved, including examining whether the formulation and implementation of a national ototoxicity monitoring guideline is necessary.
Method:
Complementary telephonic interviews were conducted with 16 senior or charge audiologists and seven senior medical oncologists from DHBs across New Zealand, and their responses analysed.
Results:
Responses indicate a comprehensive understanding of ototoxicity across both disciplines; however there is limited familiarity with ototoxicity monitoring protocols. Patients across New Zealand undergo significantly variable ototoxicity monitoring; local practices range from no routine monitoring to audiological assessment prior to each cycle of chemotherapy. No routine audiological follow up is conducted post completion of treatment at any DHB, in contrast with international guidelines. Twenty-two of 23 participants were in favour of development of a national ototoxicity monitoring guideline.
Conclusion:
There is significant discrepancy in how ototoxicity monitoring is conducted across New Zealand, and implementation of a national ototoxicity monitoring protocol may improve audiological outcomes for patients receiving ototoxic chemotherapy.
Insights
Ototoxicity monitoring varies widely in New Zealand, with no routine follow-up post-treatment. A national guideline could improve audiological outcomes for patients receiving ototoxic chemotherapy.
Area of Science:
- Oncology
- Audiology
- Pharmacovigilance
Background:
- Ototoxic chemotherapy requires careful monitoring to prevent hearing loss.
- Current ototoxicity monitoring practices in New Zealand are not standardized.
Purpose of the Study:
- To assess medical oncologists' and audiologists' knowledge of ototoxicity monitoring.
- To understand current ototoxicity monitoring protocols in New Zealand District Health Boards (DHBs).
- To explore the need for a national ototoxicity monitoring guideline.
Main Methods:
- Telephonic interviews were conducted with 16 audiologists and 7 medical oncologists across New Zealand DHBs.
- Responses were analyzed to understand current practices and attitudes towards ototoxicity monitoring.
Main Results:
- Both oncologists and audiologists demonstrated good knowledge of ototoxicity but limited familiarity with monitoring protocols.
- Significant variability exists in ototoxicity monitoring across New Zealand DHBs, from no routine monitoring to pre-chemotherapy assessment.
- No routine audiological follow-up is performed post-treatment, contrary to international standards.
- 22 out of 23 participants supported the development of a national guideline.
Conclusions:
- Discrepancies in ototoxicity monitoring across New Zealand necessitate a standardized approach.
- Implementing a national ototoxicity monitoring protocol could enhance audiological outcomes for patients on ototoxic chemotherapy.
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